منابع مشابه
A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.
The snake venom rhodocytin has been reported to bind to integrin alpha2beta1 and glycoprotein (GP) Ibalpha on platelets, but it is also able to induce activation independent of the 2 receptors and of GPVI. Using rhodocytin affinity chromatography, we have identified a novel C-type lectin receptor, CLEC-2, in platelets that confers signaling responses to rhodocytin when expressed in a cell line....
متن کاملRenal cells activate the platelet receptor CLEC-2 through podoplanin.
We have recently shown that the C-type lectin-like receptor, CLEC-2, is expressed on platelets and that it mediates powerful platelet aggregation by the snake venom toxin rhodocytin. In addition, we have provided indirect evidence for an endogenous ligand for CLEC-2 in renal cells expressing HIV-1. This putative ligand facilitates transmission of HIV through its incorporation into the viral env...
متن کاملInvolvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.
Podoplanin (aggrus), a transmembrane sialoglycoprotein, is involved in tumor cell-induced platelet aggregation, tumor metastasis, and lymphatic vessel formation. However, the mechanism by which podoplanin induces these cellular processes including its receptor has not been elucidated to date. Podoplanin induced platelet aggregation with a long lag phase, which is dependent upon Src and phosphol...
متن کاملCLEC-2 is an essential platelet activating receptor in hemostasis and thrombosis Running title: CLEC-2 in thrombosis
Address correspondence to: Bernhard Nieswandt, PhD Chair of Vascular Medicine, Rudolf Virchow Center DFG Research Center for Experimental Biomedicine University Clinic Würzburg Zinklesweg 10 97078 Würzburg Fon: + 49 931 201 44060 Fax: + 49 931 201 48068 E-mail: [email protected] Blood First Edition Paper, prepublished online July 29, 2009; DOI 10.1182/blood-2009-05-222273
متن کاملMechanisms of CLEC-2-regulated lymphangiogenesis Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells*
Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan Division of Vascular Biology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan Laboratory of Developmental Genetics, Center for Experimental Medicine and Syste...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2011
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.22.348